Basic life science research is complicated requiring innovative tools to address changing needs. Target Discovery science parallels basic research in addition to requiring innovations for shortened timelines and reduced labor. Parallel processing using high throughput liquid handling has already been accepted for assays that are generally based on simple liquid handling such as ELISA and PCR assays. However, adding chemistry to robotic liquid handling takes automation to the next level of innovation. PhyTip columns packed with custom ligand immobilized resin, activated resin conjugated with protein, streptavidin and biotin-labeled proteins, and ProA-Antibody complexes are all feasible strategies for high through target discovery. The biggest assets in a research lab are the researchers. Giving them tools to perform tedious tasks to free them up to think is the single most important technology a company can provide.