Chromatin immunoprecipitation is a variation of the immunoprecipitation and is especially useful tool in the field of epigenetics. How and where nucleosomes interact with a genome is a topic of intense study and can shed a lot of insight on gene regulation. PhyTip columns can be used to pull out chromatin in much the same way it is used to pull down protein complexes. PhyTip columns packed with activated resin can be used to covalently conjugated a bait molecule. Second, PhyTip columns packed with streptavidin can be used to immobilize a biotin-labeled bait molecule. Third, a PhyTip column packed with Protein A, Protein G, ProPlus or ProPlus LX can be used to affinity bind an antibody specific for a chromatic associated protein.